ASP 2151
- CAS NO.：841301-32-4
- Empirical Formula: C24H26N4O5S
- Molecular Weight: 482.55
- MDL number: MFCD19443709
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is ASP 2151?
Description
Amenamevir is an antiviral inhibitor of herpes simplex virus 1 (HSV-1) helicase-primase complex activity. It inhibits recombinant HSV-1 helicase with an IC50 value of 0.078 μM and recombinant HSV-1 primase when used at concentrations greater than or equal to 0.03 μM. Amenamevir inhibits replication of varicella-zoster virus (VZV), HSV-1, and HSV-2 in human embryonic fibroblast (HEF) cells (EC50s = 0.047, 0.036, and 0.028 μM, respectively) and is not cytotoxic to HEF cells with a 50% cytotoxic concentration (CC50) of greater than 30 μM. Amenamevir also inhibits replication of clinical VZV isolates in HEF cells (EC50s = 0.038-0.10 μM). In vivo, it increases survival of cutaneously HSV-1-infected mice in a zosteriform-spread model of progressive HSV-1 infection (ED50 = 1.9 mg/kg twice per day).
The Uses of ASP 2151
Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC50 of 14 ng/mL.
Properties of ASP 2151
| Density | 1.360±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.08(Max Conc. mM) DMF:2.0(Max Conc. mg/mL);4.14(Max Conc. mM) |
| form | A solid |
| pka | 12.60±0.70(Predicted) |
| color | White to off-white |
Safety information for ASP 2151
Computed Descriptors for ASP 2151
Abamectin manufacturer
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