ascofuranone
- CAS NO.:38462-04-3
- Empirical Formula: C23H29ClO5
- Molecular Weight: 420.93
- MDL number: MFCD01666362
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:38
What is ascofuranone?
The Uses of ascofuranone
(-)-Ascofuranone is an antibiotic with antitumor activity. It suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. (-)-Ascofuranone was effective in the treatment against Trypanosoma brucei brucei infection in mice.
Definition
ChEBI: Ascofuranone is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (2E,6E)-7-[(2S)-5,5-dimethyl-4-oxotetrahydrofuran-2-yl]-3-methylocta-2,6-dien-1-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by the soil fungus, Acremonium sclerotigenum. It is a promising drug candidate against the tropical disease, African trypanosomiasis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an antilipemic drug, a fungal metabolite and an antiprotozoal drug. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a tetrahydrofuranone. It is a conjugate acid of an ascofuranone(1-).
Safety Profile
Moderately toxic byintraperitoneal route. Whenheated to decomposition it emits toxic fumes of Cl-.
Properties of ascofuranone
Melting point: | 84 °C |
Boiling point: | 581.2±50.0 °C(Predicted) |
Density | 1?+-.0.06 g/cm3(Predicted) |
pka | 6.32±0.50(Predicted) |
color | Needles from Me2CO/hexane |
Safety information for ascofuranone
Computed Descriptors for ascofuranone
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin I Tubulysin A Tubulysin C Tubulysin D Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 4-(Azidomethyl)-3-chloropyridine 5-Aminophthalazine Methyl 4-amino-3-(dihexylamino)benzoate 3,3,6,6-Tetramethylcyclohexane-1,2-dione Diethyl 2,5-di(furan-2-yl)terephthalate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 6-bromo-4-methyl-2-propyl-1H-1,3-benzodiazole 3,3-dimethyl-2-oxo-, methyl ester (4-(1-Hydroxycyclobutyl)phenyl)boronic acid pinacol esterRelated products of tetrahydrofuran
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