ARZOXIFENE
- CAS NO.：182133-25-1
- Empirical Formula: C28H29NO4S
- Molecular Weight: 475.6
- MDL number: MFCD09837789
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is ARZOXIFENE?
The Uses of ARZOXIFENE
Arzoxifene is a selective estrogen receptor modulator. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.
Indications
Investigated for use/treatment in breast cancer, osteoporosis, and endometrial cancer.
Clinical Use
Arzoxifene is a third-generation SERM currently in Phase III clinical trials for the treatm ent of ER-positive recurrent/metastatic breast cancer. Similar to raloxifene, it is an ER antagonist in both breast and uterine tissues and an ER agonist on bone and the cardiovascular system. Arzoxifene is able to both preserve and build bone mineral density, which makes it a viable candidate for the treatment of osteoporosis. Ample evidence from early clinical trials indicates that arzoxifene also can be utilized as a chemopreventive agent against breast cancer.
Side Effects
Adverse effects include hot flashes (major) and headache, nausea, vomiting, and constipation (minor).
Metabolism
Not Available
Properties of ARZOXIFENE
| Melting point: | 174-176° |
| Boiling point: | 656.4±55.0 °C(Predicted) |
| Density | 1.234 |
| pka | 9.20±0.40(Predicted) |
Safety information for ARZOXIFENE
Computed Descriptors for ARZOXIFENE
New Products
Tubulysin G Tubulysin C Tubulysin A Tubulysin B tetrahydro-4-methyl-2H-pyran 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2H-Pyran, 4-ethynyltetrahydro- 3-Aminocyclobutanone hydrochloride 1-(1,1-Difluoroethyl)-2-fluorobenzene 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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