ARG-GLY-ASP
Synonym(s):L-arginyl-glycyl-L-aspartic acid
- CAS NO.:99896-85-2
- Empirical Formula: C12H22N6O6
- Molecular Weight: 346.34
- MDL number: MFCD00057952
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is ARG-GLY-ASP?
Chemical properties
White to off-white powder
The Uses of ARG-GLY-ASP
Arg-Gly-Asp has been used:
- to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
- in adhesion assay
- in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
- in textile fabrication and RGD textile functionalization
- to engineer a population of human dermal fibroblasts with impaired migration
- to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
- in the cell culture of human mammary epithelial cells
Definition
ChEBI: Arg-Gly-Asp is an oligopeptide.
General Description
Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.
Biological Activity
synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.
Biochem/physiol Actions
Primary sequence involved with the binding of proteins to cell surfaces
in vitro
rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].
in vivo
anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].
storage
Store at -20°C
References
[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.
Properties of ARG-GLY-ASP
Melting point: | 153-155℃ (ethyl ether ) |
Density | 1.61±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | Soluble in 0.1N acetic acid at 20mg/ml |
form | Powder |
pka | 2.85±0.10(Predicted) |
color | White to off-white |
Water Solubility | Soluble to 12 mg/mL
(34.64 mM) in Water |
Safety information for ARG-GLY-ASP
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P501:Dispose of contents/container to..… |
Computed Descriptors for ARG-GLY-ASP
InChIKey | IYMAXBFPHPZYIK-BQBZGAKWSA-N |
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