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HomeProduct name listARG-GLY-ASP

ARG-GLY-ASP

Synonym(s):L-arginyl-glycyl-L-aspartic acid

ARG-GLY-ASP Structural

What is ARG-GLY-ASP?

Chemical properties

White to off-white powder

The Uses of ARG-GLY-ASP

Arg-Gly-Asp has been used:

  • to saturate the cell surface Arg-Gly-Asp (RGD) receptors and inhibit marrow stromal cell (MSC) attachment to peptide modified hydrogel
  • in adhesion assay
  • in inhibition assay to confirm the β1-integrin-dependency of cell adhesion
  • in textile fabrication and RGD textile functionalization
  • to engineer a population of human dermal fibroblasts with impaired migration
  • to modify glass substrate and evaluate the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs)
  • in the cell culture of human mammary epithelial cells

Definition

ChEBI: Arg-Gly-Asp is an oligopeptide.

General Description

Arg-Gly-Asp (RGD) is an integrin binding site, which belongs to the class of adhesive proteins. It functions as a brain tumor targeting ligand.

Biological Activity

synthetic peptides containing the arginine-glycine-aspartate (rgd) were extensively used as inhibitors of integrin-ligand interactions in studies of cell adhesion, migration, growth and differentiation, since the rgd motif is an integrin-recognition motif found in many ligands.

Biochem/physiol Actions

Primary sequence involved with the binding of proteins to cell surfaces

in vitro

rgd peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. previous study demonstrates that rgd peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing [1].

in vivo

anima study suggested that the rgd-4c-fitc-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells [2].

storage

Store at -20°C

References

[1] nature. 1999 feb 11;397(6719):534-9.rgd peptides induce apoptosis by direct caspase-3 activation. buckley cd1, pilling d, henriquez nv, parsonage g, threlfall k, scheel-toellner d, simmons dl, akbar an, lord jm, salmon m.
[2] cancer res. 2002 sep 15;62(18):5139-43. arginine-glycine-aspartic acid (rgd)-peptide binds to both tumor and tumor-endothelial cells in vivo. zitzmann s1, ehemann v, schwab m.

Properties of ARG-GLY-ASP

Melting point: 153-155℃ (ethyl ether )
Density  1.61±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in 0.1N acetic acid at 20mg/ml
form  Powder
pka 2.85±0.10(Predicted)
color  White to off-white
Water Solubility  Soluble to 12 mg/mL (34.64 mM) in Water

Safety information for ARG-GLY-ASP

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P501:Dispose of contents/container to..…

Computed Descriptors for ARG-GLY-ASP

InChIKey IYMAXBFPHPZYIK-BQBZGAKWSA-N

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