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HomeProduct name listARACHIDOYL ETHANOLAMIDE

ARACHIDOYL ETHANOLAMIDE

ARACHIDOYL ETHANOLAMIDE Structural

What is ARACHIDOYL ETHANOLAMIDE?

Description

The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.1,2 Arachidoyl ethanolamide is one of the saturated fatty acyl ethanolamides devoid of classical (CB1/CB2) activity. Arachidoyl ethanolamide does not bind to the murine CB1 receptor3 and does not compete with anandamide as a substrate for the endocannabinoid hydrolytic enzyme fatty acid amide hydrolase.4 Non-CB receptor-mediated pharmacology of the saturated ethanolamides is still being elucidated.5

What are the applications of Application

Arachidoyl Ethanolamide is an atypical saturated fatty acyl ethanolamide

Definition

ChEBI: N-(icosanoyl)ethanolamine is an N-(long-chain-acyl)ethanolamine that is the ethanolamide of eicosanoic acid. It is a N-(long-chain-acyl)ethanolamine and a N-(saturated fatty acyl)ethanolamine. It is functionally related to an icosanoic acid.

References

1. Martin, B.R., Mechoulam, R., and Razdan, R.K. Discovery and characterization of endogenous cannabinoids Life Sci. 65,573-595(1999).
2. Pertwee, R.G. Pharmacology of cannabinoid receptor ligands Curr. Med. Chem. 6(8),635-664(1999).
3. Sheskin, T., Hanus, L., Slager, J., et al. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor J. Med. Chem. 40,659-667(1997).
4. Desarnaud, F., Cadas, H., and Piomelli, D. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization J. Biol. Chem. 270(11),6030-6035(1995).
5. Smart, D., Jonsson, K.O., Vandevoorde, S., et al. “Entourage” effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism Br. J. Pharmacol. 136,452-458(2002).

Properties of ARACHIDOYL ETHANOLAMIDE

solubility  DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 2.5 mg/ml; PBS (pH 7.2): .15 mg/ml
form  A crystalline solid

Safety information for ARACHIDOYL ETHANOLAMIDE

Computed Descriptors for ARACHIDOYL ETHANOLAMIDE

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