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HomeProduct name listAPROBARBITAL METHANOL SOLUTION

APROBARBITAL METHANOL SOLUTION

APROBARBITAL METHANOL SOLUTION Structural

What is APROBARBITAL METHANOL SOLUTION?

Originator

Alurate,Roche

The Uses of APROBARBITAL METHANOL SOLUTION

Controlled substance (depressant). Sedative, hypnotic.

Definition

ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by an isopropyl and a prop-1-en-3-yl group at position 5.

Manufacturing Process

170 parts of isopropylbarbituric acid are mixed with 500 parts of water and dissolved by adding 135 parts of a 30 percent of the solution of sodium hydroxide. To this solution are added 130 parts of 130 parts of allylbromide. An emulsion obtained is stirred at an inner temperature of about 25°C. The reaction is at first accompanied by a slight development of heat. After 12 hours the reaction is brought to a close. When cooled down the isopropylallylbarbituric acid is drawn off. The yield is more than 80 percent of the theoretically calculated quantity. By crystallization from diluted alcohol the pure isopropylallylbarbituric acid is obtained in colorless crystals of the melting point 137-138°C.

Therapeutic Function

Sedative, Hypnotic

World Health Organization (WHO)

Aprobarbital is an intermediate-acting barbiturate. See WHO comment for barbiturates.

Properties of APROBARBITAL METHANOL SOLUTION

Melting point: 140-141.5°
Boiling point: 349.75°C (rough estimate)
Density  1.2056 (rough estimate)
refractive index  1.5000 (estimate)
storage temp.  2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
pka 7.81±0.10(Predicted)
form  Solid
color  White to Off-White
Water Solubility  4.121g/L(25 ºC)

Safety information for APROBARBITAL METHANOL SOLUTION

Computed Descriptors for APROBARBITAL METHANOL SOLUTION

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