Angeli’s Salt
Synonym(s):Angeli’s Salt - CAS 13826-64-7 - Calbiochem;Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
- CAS NO.:13826-64-7
- Empirical Formula: N2Na3O3+
- Molecular Weight: 144.98
- MDL number: MFCD33404171
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Angeli’s Salt?
Description
The chemical feat that perhaps best illustrates Angeli's intuitive talent was the discovery more than a century ago of the sodium salt of nitroxylaminic acid, also called Angeli's Salt (Na2N2O3). Na2[ON=NO2] is regarded as a classic nitroxyl(N=O-) donor, but under certain conditions evolution of NO is also observed. Angelo Angeli found that'salts of nitroxylaminic acid are readily resolved into the corresponding nitrites and the unsaturated nitroxyl residue. Angeli suggested their use as possible in vitro and in vivo sources of HNO,but physiological properties of this molecule didn't attract very much attention until the end of the 20th century.
Angeli's salt can be conveniently synthesized by treating hydroxylamine hydrochloride with excess sodium hydroxide,yielding hydroxylamine,which is further treated with butyl nitrate to produce the salt as a white solid.
The Uses of Angeli’s Salt
HNO/NO- donor in biochemical model studies.
The Uses of Angeli’s Salt
Sodium Oxyhyponitrite is used in the treatment for hemolysis.
What are the applications of Application
Angeli′s salt is a NO donor salt with demonstrated cytotoxicity
General Description
A nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t?) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
Biochem/physiol Actions
Primary TargetNitroxyl anion (NO-) donor
Properties of Angeli’s Salt
Density | 2.26 (monohydrate) |
storage temp. | Store at -20°C |
solubility | H20: 50 mg/ml; PBS (pH 7.2): 50 mg/ml |
form | A crystalline solid |
Safety information for Angeli’s Salt
Computed Descriptors for Angeli’s Salt
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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