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HomeProduct name listAmprolium Hydrochloride

Amprolium Hydrochloride

Synonym(s):1-([4-Amino-2-propyl-5-pyrimidinyl]methyl)-2-methylpyridinium chloride

  • CAS NO.:137-88-2
  • Empirical Formula: C14H20Cl2N4
  • Molecular Weight: 315.24
  • MDL number: MFCD00078831
  • EINECS: 205-307-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
Amprolium Hydrochloride Structural

What is Amprolium Hydrochloride?

Description

Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.

Chemical properties

Crystalline powder

The Uses of Amprolium Hydrochloride

Coccidiostatic;Thiamine transport inhibitor

The Uses of Amprolium Hydrochloride

1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.

The Uses of Amprolium Hydrochloride

Thiamine analog coccidiostat.

What are the applications of Application

Amprolium HCl is a thiamine analog coccidiostat

Definition

MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Veterinary Drugs and Treatments

Amprolium has good activity against Eimeria tenella and E. acervulina in poultry and can be used as a therapeutic agent for these organisms. It only has marginal activity or weak activity against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in combination with other agents (e.g., ethopabate) to improve control against those organisms.
In cattle, amprolium has approval for the treatment and prevention of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the control of coccidiosis, although there are no approved products in the USA for these species.

Properties of Amprolium Hydrochloride

Melting point: 239.0 to 243.0 °C
storage temp.  Inert atmosphere,Room Temperature
solubility  Methanol (Slightly), Water (Slightly)
form  Powder
color  White to Off-white
BRN  4118699
InChI InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
CAS DataBase Reference 137-88-2(CAS DataBase Reference)
EPA Substance Registry System Amprolium hydrochloride (137-88-2)

Safety information for Amprolium Hydrochloride

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H317:Sensitisation, Skin
H334:Sensitisation, respiratory
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P284:Wear respiratory protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

Computed Descriptors for Amprolium Hydrochloride

InChIKey PJBQYZZKGNOKNJ-UHFFFAOYSA-M
SMILES C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-]

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