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HomeProduct name listAMASTATIN HYDROCHLORIDE

AMASTATIN HYDROCHLORIDE

Synonym(s):(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate

  • CAS NO.:100938-10-1
  • Empirical Formula: C21H39ClN4O8
  • Molecular Weight: 511.01
  • MDL number: MFCD00058071
  • EINECS: 999-999-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
AMASTATIN HYDROCHLORIDE Structural

What is AMASTATIN HYDROCHLORIDE?

The Uses of AMASTATIN HYDROCHLORIDE

Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical]

What are the applications of Application

Amastatin hydrochloride is a competitive inhibitor of several aminopeptidases

General Description

Chemical structure: peptide

Biochem/physiol Actions

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM.

storage

+4°C

Properties of AMASTATIN HYDROCHLORIDE

Melting point: 202-205 °C
storage temp.  -20°C
solubility  methanol: 5 mg/mL, clear, colorless
form  White to off-white powder.
color  White to off-white
BRN  8888370

Safety information for AMASTATIN HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for AMASTATIN HYDROCHLORIDE

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