AMASTATIN HYDROCHLORIDE
Synonym(s):(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate
- CAS NO.:100938-10-1
- Empirical Formula: C21H39ClN4O8
- Molecular Weight: 511.01
- MDL number: MFCD00058071
- EINECS: 999-999-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-20 18:13:44
What is AMASTATIN HYDROCHLORIDE?
The Uses of AMASTATIN HYDROCHLORIDE
Amastatin is a slow, tight binding, competitive aminopeptidase (AP) inhibitor, first described as an inhibitor of human serum AP-A (glutamyl AP; IC50 = 0.54 μg/ml) but not of AP-B (arginine AP). It also inhibits AP-N (AP-M, alanyl AP; Ki = 20-200 nM), leucyl-cystinyl AP (Ki = 20-220 nM), and endoplasmic reticulum AP 1 (Ki = 41.8 μM). Amastatin is without effect on trypsin, papain, chymotrypsin, elastase, pepsin, or thermolysin.[Cayman Chemical]
What are the applications of Application
Amastatin hydrochloride is a competitive inhibitor of several aminopeptidases
General Description
Chemical structure: peptide
Biochem/physiol Actions
It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.Effective concentration: 1-10 μM.
storage
+4°C
Properties of AMASTATIN HYDROCHLORIDE
Melting point: | 202-205 °C |
storage temp. | -20°C |
solubility | methanol: 5 mg/mL, clear, colorless |
form | White to off-white powder. |
color | White to off-white |
BRN | 8888370 |
Safety information for AMASTATIN HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for AMASTATIN HYDROCHLORIDE
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