ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
- CAS NO.:10129-56-3
- Empirical Formula: C8H8Cl3NO
- Molecular Weight: 240.51
- MDL number: MFCD00177920
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL?
The Uses of ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
PETCM is a caspace-3 activator in cell extracts.
What are the applications of Application
PETCM is a caspace-3 activator in cell extracts
Definition
ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.
Biological Activity
petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].
storage
Room temperature
References
[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.
Properties of ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
Boiling point: | 342.2±37.0 °C(Predicted) |
Density | 1.465±0.06 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | DMSO: 22 mg/mL, soluble |
form | solid |
pka | 12.07±0.20(Predicted) |
color | Light yellow to light brown |
Safety information for ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
Computed Descriptors for ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL
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