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HomeProduct name listALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL Structural

What is ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL?

The Uses of ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

PETCM is a caspace-3 activator in cell extracts.

What are the applications of Application

PETCM is a caspace-3 activator in cell extracts

Definition

ChEBI: 1,1,1-trichloro-3-pyridin-4-yl-2-propanol is a member of pyridines.

Biological Activity

petcm is an activator of caspase-3 [1].caspase-3 is a member of the cysteine-aspartic acid protease family and interacts with caspase-8 and caspase-9. sequential activation of caspases plays an important role in cell apoptosis.in hela s-100 cell cytosol, petcm activated caspase-3 in a dose-dependent way and induced apoptosome formation. petcm (0.2 mm) caused apaf-1 shifted to a size of ~1 million daltons, which indicating apoptosome formation. also, petcm function required datp. the activation effect of petcm on caspase-3 was independent of phap proteins. when inhibited the activation activity of the phap proteins, petcm reversed the suppression. when added to q30 (apaf-1/procaspase-9) plus cytochrome c and 10 μm datp, recombinant phapi activated caspase-3. the activity was inhibited by recombinant prot. while, petcm reversed the inhibitory effect of prot. phapi didn’t affect apoptosome formation and activated caspase-9 and apaf-1, which were associated with apoptosome. prot efficiently blocked formation of apoptosome and petcm relieved this effect [1].

storage

Room temperature

References

[1]. jiang x, kim he, shu h, et al. distinctive roles of phap proteins and prothymosin-alpha in a death regulatory pathway. science, 2003, 299(5604): 223-226.

Properties of ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

Boiling point: 342.2±37.0 °C(Predicted)
Density  1.465±0.06 g/cm3(Predicted)
storage temp.  Store at RT
solubility  DMSO: 22 mg/mL, soluble
form  solid
pka 12.07±0.20(Predicted)
color  Light yellow to light brown

Safety information for ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

Computed Descriptors for ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL

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