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HomeProduct name listALPHA-CYANO-4-HYDROXYCINNAMIC ACID

ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

  • CAS NO.:28166-41-8
  • Empirical Formula: C10H7NO3
  • Molecular Weight: 189.17
  • MDL number: MFCD00004204
  • EINECS: 248-879-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-28 15:15:04
ALPHA-CYANO-4-HYDROXYCINNAMIC ACID Structural

What is ALPHA-CYANO-4-HYDROXYCINNAMIC ACID?

Chemical properties

yellow crystalline powder

The Uses of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

inhibitor of mitochondrial pyruvate transport

The Uses of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

The Uses of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

α-Cyano-4-hydroxycinnamic acid(CHC) was used as a matrix for peptides and nucleotides in mass spectroscopic analysis. It was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.

Definition

ChEBI: Alpha-cyano-4-hydroxycinnamic acid is a monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides. It has a role as a MALDI matrix material. It is a nitrile, a member of phenols and a monohydroxycinnamic acid.

General Description

α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase.

Biochem/physiol Actions

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM).

storage

Store at +4°C

Properties of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

Melting point: 245-250 °C(lit.)
Boiling point: 324.41°C (rough estimate)
Density  1.3175 (rough estimate)
refractive index  1.5400 (estimate)
storage temp.  2-8°C
solubility  methanol: 10 mg/mL, clear
form  powder
pka 0.85±0.10(Predicted)
color  yellow
BRN  3271427
CAS DataBase Reference 28166-41-8(CAS DataBase Reference)

Safety information for ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H317:Sensitisation, Skin
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for ALPHA-CYANO-4-HYDROXYCINNAMIC ACID

InChIKey AFVLVVWMAFSXCK-VMPITWQZSA-N

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