ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
- CAS NO.:28166-41-8
- Empirical Formula: C10H7NO3
- Molecular Weight: 189.17
- MDL number: MFCD00004204
- EINECS: 248-879-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-28 15:15:04
What is ALPHA-CYANO-4-HYDROXYCINNAMIC ACID?
Chemical properties
yellow crystalline powder
The Uses of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
inhibitor of mitochondrial pyruvate transport
The Uses of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
α-Cyano-4-hydroxycinnamic acid (CHC) was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.
The Uses of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
α-Cyano-4-hydroxycinnamic acid(CHC) was used as a matrix for peptides and nucleotides in mass spectroscopic analysis. It was used in encapsulation of CHC into NaY zeolite. It was used as matrix to investigate the activity of the paclitaxel derivatives using several well-established in vitro angiogenesis assays.
Definition
ChEBI: Alpha-cyano-4-hydroxycinnamic acid is a monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides. It has a role as a MALDI matrix material. It is a nitrile, a member of phenols and a monohydroxycinnamic acid.
General Description
α-Cyano-4-hydroxycinnamic acid is the commonly used matrix for analyzing peptides by matrix-assisted laser desorption/ionization mass spectrometry. It inhibits the monophenolase activity and diphenolase activity of mushroom tyrosinase.
Biochem/physiol Actions
α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport. It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM).
storage
Store at +4°C
Properties of ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
Melting point: | 245-250 °C(lit.) |
Boiling point: | 324.41°C (rough estimate) |
Density | 1.3175 (rough estimate) |
refractive index | 1.5400 (estimate) |
storage temp. | 2-8°C |
solubility | methanol: 10 mg/mL, clear |
form | powder |
pka | 0.85±0.10(Predicted) |
color | yellow |
BRN | 3271427 |
CAS DataBase Reference | 28166-41-8(CAS DataBase Reference) |
Safety information for ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ALPHA-CYANO-4-HYDROXYCINNAMIC ACID
InChIKey | AFVLVVWMAFSXCK-VMPITWQZSA-N |
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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