ALPHA-APO-OXYTETRACYCLINE
- CAS NO.:18751-99-0
- Empirical Formula: C22H22N2O8
- Molecular Weight: 442.42
- MDL number: MFCD00062827
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is ALPHA-APO-OXYTETRACYCLINE?
Description
β-Apooxytetracycline is a potential impurity found in commercial preparations of oxytetracycline. β-Apooxytetracycline is a degradation product formed from oxytetracycline via acid hydrolysis. It has a relative potency of 0.1 compared with oxytetracycline for inhibiting the growth of aerobic sludge bacteria, an MIC50 value of 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and MIC50 values of greater than 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Moraxella, and Bacillus, as well as tetracycline-resistant strains of E. coli. β-Apooxytetracycline (10 mg/kg) is toxic to rats, decreasing body weight, disrupting blood cell counts, and inducing hepatocyte necrosis.
Chemical properties
yellow-brown to brown powder
The Uses of ALPHA-APO-OXYTETRACYCLINE
Oxytetracycline metabolite (absolute stereochemistry unknown)
The Uses of ALPHA-APO-OXYTETRACYCLINE
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. An initial dehydration to anhydrooxytetracycline then undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-apooxytetracycline is an important standard for monitoring oxytetracycline stability.
The Uses of ALPHA-APO-OXYTETRACYCLINE
β-Apooxytetracycline is a degradation product of oxytetracycline formed under acidic conditions. After initial dehydration to anhydrooxytetracycline, it undergoes an internal cyclisation of the C5-OH to the C12 ketone. The resulting cleavage of the C12-C12a bond generates two isomers, α- and β-apooxytetracycline. β-Apooxytetracycline is an important standard for monitoring oxytetracycline stability.
What are the applications of Application
β-Apo-oxytetracycline is An Oxytetracycline metabolite
Properties of ALPHA-APO-OXYTETRACYCLINE
Melting point: | 200-204 °C |
Boiling point: | 742.4±60.0 °C(Predicted) |
Density | 1.62±0.1 g/cm3(Predicted) |
storage temp. | Refrigerator, Under Inert Atmosphere |
solubility | Aqueous Base (Slightly), Methanol (Slightly, Heated, Sonicated) |
pka | 1.62±0.58(Predicted) |
form | Powder |
color | Yellow-brown to brown |
Stability: | Unstable in basic solution |
EPA Substance Registry System | 1-Cyclohexene-1-carboxamide, 4-(1,3-dihydro-4,5-dihydroxy-9-methyl-3-oxonaphtho[2,3-c]furan-1-yl)-3-(dimethylamino)-2,5-dihydroxy-6-oxo- (18751-99-0) |
Safety information for ALPHA-APO-OXYTETRACYCLINE
Computed Descriptors for ALPHA-APO-OXYTETRACYCLINE
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