AICAR (phosphate)
- CAS NO.:681006-28-0
- Empirical Formula: C9H17N4O9P
- Molecular Weight: 356.23
- MDL number: MFCD23726600
- Update Date: 2024-07-02 08:55:20
What is AICAR (phosphate)?
Biological Activity
aicar phosphate (acadesine)is an activator of ampk [1].aicar phosphate has been reported to induce apoptosis in a dose-dependent fashion and that the ec50 value is 380±60μm on the viability assay of b-cll cells. in addition, aicar phosphate has been revealed to induce caspase activation and cytochrome c release from mitochondria in b-cll cells. furthermore, aicar phosphate has shown that uptake and phosphorylation are required to induce apoptosis and activate ampk. apart from these, aicar phosphate (2-4 mm) has shown to only slightly affects the viability of t cells from b-cll patients, aicar phosphate (0.5 mm) has been noted to remarkedly reduces viability of b cells but not t cells [1].
References
[1] campàs c1, lopez jm, santidrián af, barragán m, bellosillo b, colomer d, gil j. acadesine activates ampk and induces apoptosis in b-cell chronic lymphocytic leukemia cells but not in t lymphocytes. blood. 2003 may 1;101(9):3674-80. epub 2003 jan 9.
Properties of AICAR (phosphate)
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | Solid |
color | White to off-white |
Safety information for AICAR (phosphate)
Computed Descriptors for AICAR (phosphate)
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