AHU-377 (heMicalciuM salt)

Synonym(s):(2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester;4-[[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid calcium salt;4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester;AHU377 calcium salt;AHU-377 calcium salt

CAS NO.：1369773-39-6
Empirical Formula: C48H56CaN2O10
Molecular Weight: 861.04364
MDL number: MFCD28137893
EINECS: 935-847-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is AHU-377 (heMicalciuM salt)?

The Uses of AHU-377 (heMicalciuM salt)

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

storage

Store at -20°C

Properties of AHU-377 (heMicalciuM salt)

Melting point:	>140°C (dec.)
Density	1.24g/cm3 at 20℃
vapor pressure	0.001Pa at 20℃
storage temp.	-20°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly)
form	powder
color	white to beige

Safety information for AHU-377 (heMicalciuM salt)

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.