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HomeProduct name listAHU-377 (heMicalciuM salt)

AHU-377 (heMicalciuM salt)

Synonym(s):(2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester;4-[[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid calcium salt;4-{[(2S,4R)-1-(4-Biphenylyl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid; (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester;AHU377 calcium salt;AHU-377 calcium salt

  • CAS NO.：1369773-39-6
  • Empirical Formula: C48H56CaN2O10
  • Molecular Weight: 861.04364
  • MDL number: MFCD28137893
  • EINECS: 935-847-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
AHU-377 (heMicalciuM salt) Structural

What is AHU-377 (heMicalciuM salt)?

The Uses of AHU-377 (heMicalciuM salt)

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Biochem/physiol Actions

Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization.

storage

Store at -20°C

Properties of AHU-377 (heMicalciuM salt)

Melting point: >140°C (dec.)
Density  1.24g/cm3 at 20℃
vapor pressure  0.001Pa at 20℃
storage temp.  -20°C
solubility  DMSO (Slightly, Heated), Methanol (Slightly)
form  powder
color  white to beige

Safety information for AHU-377 (heMicalciuM salt)

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H301:Acute toxicity,oral
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for AHU-377 (heMicalciuM salt)

AHU-377 (heMicalciuM salt) manufacturer

Svak Life Sciences

1Y
Phone:+91-9705383777
Whatsapp: +91 9705383777
product: Sacubitril calcium salt 98%
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ExSyn Corp

1Y
Phone:+912240546474
product: Sacubitril calcium salt 1369773-39-6 98%
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Venkatasai Life Sciences

1Y
Phone:+91-8008303069
Whatsapp: +91 8008303069
product: 1369773-39-6 Sacubitril calcium salt 99%
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Ami Lifesciences Pvt Ltd

1Y
Phone:+91-9426998100
Whatsapp: +91-9426998100
product: 1369773-39-6 99%
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Orgamine Chemicals(I) Pvt Ltd

1Y
Phone:+91-2512871746
product: Sacubitril calcium salt 98%
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Related products of tetrahydrofuran

(R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
(R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate
(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid
Valsartan
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sacubitril
sacubitril
Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate
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((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester
((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester

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