AG 490

Synonym(s):2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

CAS NO.：134036-52-5
Empirical Formula: C17H14N2O3
Molecular Weight: 294.3
MDL number: MFCD00209833
EINECS: 604-604-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is AG 490?

Chemical properties

Pale Yellow-Green Crystal

The Uses of AG 490

A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

The Uses of AG 490

Tyrphostin B42 is used in acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors.

Definition

ChEBI: Tyrphostin B42 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antioxidant, a STAT3 inhibitor, an anti-inflammatory agent, an apoptosis inducer and a geroprotector. It is an enamide, a monocarboxylic acid amide, a nitrile, a member of catechols and a secondary carboxamide.

Properties of AG 490

Melting point:	215
Boiling point:	615.2±55.0 °C(Predicted)
Density	1.337±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	ethanol: 5 mg/mL
form	solid
pka	8.82±0.35(Predicted)
color	yellow
CAS DataBase Reference	134036-52-5(CAS DataBase Reference)

Safety information for AG 490

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.