Afurolol
- CAS NO.:65776-67-2
- Empirical Formula: C15H21NO4
- Molecular Weight: 279.33154
- MDL number: MFCD00864583
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is Afurolol?
Originator
Afurolol ,ZYF Pharm Chemical
Manufacturing Process
A mixture of 18.0 g (0.12 mole) 7-hydroxyphthalide, 180.0 g of 1-chloro-2,3-
epoxypropane (2 moles) and 0.5 ml of piperidine is heated at 100°C for about
5 h and then the unreacted 1-chloro-2,3-epoxypropane is distilled off in
vacuum to yield 12.0 g (48%) of 7-(2,3-epoxypropoxy)phthalide, melting
point 88°-90°C, (crystallized successively from methanol and ethyl acetate).
The 7-(2,3-epoxypropoxy)phthalide is dissolved in methanol and t-butylamine
are added to the solution at about 20°C. The solution is allowed to stand overnight and, the mixture is evaporated in vacuum and the residue is dried
to give 7-(2-hydroxy-3-t-butylamino-propoxy)phthalide.
Therapeutic Function
Beta-adrenergic blocker
Safety information for Afurolol
New Products
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AKOS BC-1937
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Xibenolol
2-(2-HYDROXY-ETHOXY)-BENZOIC ACID METHYL ESTER
Afurolol
toliprolol
2-(2-HYDROXY-ETHOXY)-BENZOIC ACID
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