Adrenalone
- CAS NO.:99-45-6
- Empirical Formula: C9H11NO3
- Molecular Weight: 181.19
- MDL number: MFCD00707523
- EINECS: 202-756-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:44
What is Adrenalone?
Originator
Adrenalone ,Yick-Vic Chemicals and Pharmaceuticals (HK) Ltd.
The Uses of Adrenalone
Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor.
The Uses of Adrenalone
Adrenergic (ophthalmic).
Preparation
Preparation by reaction of excess 33% aqueous methylamine with 3,4-dihydroxy-a-chloroacetophenone.
Definition
ChEBI: Adrenalone is an aromatic ketone.
Manufacturing Process
To a suspension of 1 part ω-chloro-3,4-dihydroxyacetophenone (prerared from chloroacetyl chloride and benzcatechole, see J. Russ. Phys. Chem. Ges., 25, 154) was added dropwise 1 part 60% solution of methylamine. Immediately was formed a residue of the salt of methylamine and ω-chloro-3,4- dihydroxyacetophenone. The dissolution of the salt was carried out by heating of the mixture. Then the salt was converted in crude 3,4-dihydroxy-α- methylaminoacetophenone. The product was dissolved in dilute hydrochloric acid. To this solution was added dropwise aqueous ammonium solution to prepare light yellow crystal of 3,4-dihydroxy-α-methylaminoacetophenone. The base and the hydrochloride of 3,4-dihydroxy-α-methylaminoacetophenone decomposed at temperature near 230°C and 240°C respectively.
Therapeutic Function
Hemostatic, Sympathomimetic, Vasoconstrictor
Properties of Adrenalone
Melting point: | 235.5°C (rough estimate) |
Boiling point: | 314.29°C (rough estimate) |
Density | 1.2375 (rough estimate) |
refractive index | 1.5270 (estimate) |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | Aqueous Acid (Slightly) |
form | Solid |
pka | 7.32±0.20(Predicted) |
color | Pale Yellow to Light Yellow |
Stability: | Hygroscopic |
Safety information for Adrenalone
Computed Descriptors for Adrenalone
Adrenalone manufacturer
Molsyns Research
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