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HomeProduct name listAdrenalone

Adrenalone

  • CAS NO.:99-45-6
  • Empirical Formula: C9H11NO3
  • Molecular Weight: 181.19
  • MDL number: MFCD00707523
  • EINECS: 202-756-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:44
Adrenalone Structural

What is Adrenalone?

Originator

Adrenalone ,Yick-Vic Chemicals and Pharmaceuticals (HK) Ltd.

The Uses of Adrenalone

Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor.

The Uses of Adrenalone

Adrenergic (ophthalmic).

Preparation

Preparation by reaction of excess 33% aqueous methylamine with 3,4-dihydroxy-a-chloroacetophenone.

Definition

ChEBI: Adrenalone is an aromatic ketone.

Manufacturing Process

To a suspension of 1 part ω-chloro-3,4-dihydroxyacetophenone (prerared from chloroacetyl chloride and benzcatechole, see J. Russ. Phys. Chem. Ges., 25, 154) was added dropwise 1 part 60% solution of methylamine. Immediately was formed a residue of the salt of methylamine and ω-chloro-3,4- dihydroxyacetophenone. The dissolution of the salt was carried out by heating of the mixture. Then the salt was converted in crude 3,4-dihydroxy-α- methylaminoacetophenone. The product was dissolved in dilute hydrochloric acid. To this solution was added dropwise aqueous ammonium solution to prepare light yellow crystal of 3,4-dihydroxy-α-methylaminoacetophenone. The base and the hydrochloride of 3,4-dihydroxy-α-methylaminoacetophenone decomposed at temperature near 230°C and 240°C respectively.

Therapeutic Function

Hemostatic, Sympathomimetic, Vasoconstrictor

Properties of Adrenalone

Melting point: 235.5°C (rough estimate)
Boiling point: 314.29°C (rough estimate)
Density  1.2375 (rough estimate)
refractive index  1.5270 (estimate)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  Aqueous Acid (Slightly)
form  Solid
pka 7.32±0.20(Predicted)
color  Pale Yellow to Light Yellow
Stability: Hygroscopic

Safety information for Adrenalone

Computed Descriptors for Adrenalone

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