ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
Synonym(s):Adenosine 5′-triphosphate-2′,3′-dialdehyde;oATP;Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem;Purinergic Receptor Antagonist, Oxidized ATP, Purinergic Receptor P2X7 Antagonist, Oxidized ATP, Purinergic Receptor Inhibitor, Oxidized ATP, O-ATP
- CAS NO.：71997-40-5
- Empirical Formula: C10H13N5NaO13P3
- Molecular Weight: 527.15
- MDL number: MFCD00056956
- Update Date: 2024-07-02 08:55:05
What is ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT?
The Uses of ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
- as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
- as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
- to evaluate the physiological significance of elevated intracellular ATP levels
- increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells
What are the applications of Application
Adenosine 5′-triphosphate, periodate oxidized sodium salt is an inhibitor of P2x receptors
General Description
A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
Biochem/physiol Actions
Reversible: no
Properties of ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
| storage temp. | -20°C |
| form | White powder |
| color | White to off-white |
Safety information for ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
Computed Descriptors for ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
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