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HomeProduct name listACT-132577

ACT-132577

ACT-132577 Structural

What is ACT-132577?

The Uses of ACT-132577

N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)

Definition

ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

Properties of ACT-132577

Melting point: 139-141°C
Boiling point: 705.0±70.0 °C(Predicted)
Density  1.841±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
form  Solid
pka 13.56±0.60(Predicted)
color  White to Off-White

Safety information for ACT-132577

Computed Descriptors for ACT-132577

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