ACT-132577
- CAS NO.：1103522-45-7
- Empirical Formula: C16H14Br2N6O4S
- Molecular Weight: 546.19
- MDL number: MFCD28155267
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-28 19:59:05
What is ACT-132577?
The Uses of ACT-132577
N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
Definition
ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.
Properties of ACT-132577
| Melting point: | 139-141°C |
| Boiling point: | 705.0±70.0 °C(Predicted) |
| Density | 1.841±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 13.56±0.60(Predicted) |
| color | White to Off-White |
Safety information for ACT-132577
Computed Descriptors for ACT-132577
Abamectin manufacturer
Varanous Labs Pvt Ltd
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(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin F Tubulysin B Tubulysin H 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one 3,6-Dihydro-2H-pyran-4-carbonitrile 5-Methyl-1-indanone CYCLOBUTYLAMINE HYDROCHLORIDE 3-N-BOC-(S)-AMINO BUTYRONITRILE Cyclobutanamine, 3,3-difluoro- (9CI) 1-(4-amino-2- methylbenzoyl)-7- chloro-3,4-dihydro- 1H-benzo[b] azepin-5(2H)-one 3-(4-Chloro-butyryl) -1H-indole-5- carbonitrile (S)-3-(3-fluoro- 4-thiomorpholinophenyl) -4-(hydroxymethyl) oxazolidin-2-one 4-(2-fluoro-4- nitrophenyl) thiomorpholine 2-(2-Formylphenoxy) acetic acid 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid (R)-methyl 2-formamido-3-(tritylthio)propanoate (R)-methyl 2-isocyano-3-(tritylthio)propanoate HALOPERIDOL DECANOATE EP IMPURITY B Sitagliptin FP Impurity D / Sitagliptin Phenylcrotonyl Analog (USP) Quetiapine S-Oxide 7-Hydroxy MetaboliteYou may like
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