ACT-132577
- CAS NO.:1103522-45-7
- Empirical Formula: C16H14Br2N6O4S
- Molecular Weight: 546.19
- MDL number: MFCD28155267
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is ACT-132577?
The Uses of ACT-132577
N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
Definition
ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.
Properties of ACT-132577
Melting point: | 139-141°C |
Boiling point: | 705.0±70.0 °C(Predicted) |
Density | 1.841±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) |
form | Solid |
pka | 13.56±0.60(Predicted) |
color | White to Off-White |
Safety information for ACT-132577
Computed Descriptors for ACT-132577
Abamectin manufacturer
Varanous Labs Pvt Ltd
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