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1103522-45-7

1103522-45-7 structural image
Product Name: ACT-132577
Formula: C16H14Br2N6O4S
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COMPUTED DESCRIPTORS

Molecular Weight 546.2 g/mol
XLogP3 2.4
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 10
Rotatable Bond Count 8
Exact Mass 545.91435 g/mol
Monoisotopic Mass 543.91640 g/mol
Topological Polar Surface Area 151 Ų
Heavy Atom Count 29
Formal Charge 0
Complexity 597
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol.

RELATED SUPPLIERS

Varanous Labs Pvt Ltd

1Y
product:1103522-45-7 Macitentan ACT-132577 98%
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