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Aceperone

Aceperone Structural

What is Aceperone?

Originator

Aceperone ,ZYF Pharm Chemical

Manufacturing Process

A mixture of 1-benzyl-4-(4-phenyl)-4-(acetaminomethyl)piperidine, 3-(4- fluorobenzoyl)propyl bromide, sodium bicarbonate and anhydrous acetone was stirred and heated under reflux. The resulting mixture was filtered while still hot, and the filtrate was concentrated to dryness under reduced pressure. The residue was washed with ether to give 1-benzyl-1-[3-(4-fiuorobenzoyl)propyl]- (4-phenyl-4-acetaminomethyl)piperidinium bromide.
To a stirred mixture of thiophenol and 15% (W/W) aqueous sodium hydroxide was added the 1-benzyl-1-[3-(4-fluorobenzoyl)propyl]-(4-phenyl-4- acetaminomethyl)piperidinium bromide and the mixture was heated to 85°- 90°C for 2 h. After cooling, solid matter precipitated was collected by filtration and washed with water to give 1-[3-(4-fluorobenzoyl)propyl]-4- (acetaminomethyl)-4-phenylpiperidine, melting point 111°-112°C.

Therapeutic Function

Vasodilator, Antihypertensive, Neuroleptic

Properties of Aceperone

Melting point: 97-100°
CAS DataBase Reference 807-31-8

Safety information for Aceperone

Computed Descriptors for Aceperone

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