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HomeProduct name listAC-YVAD-CMK

AC-YVAD-CMK

Synonym(s):Ac-Tyr-Val-Ala-Asp-Chloromethylketone;Caspase-1 Inhibitor II - CAS 178603-78-6 - Calbiochem;IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK;N-Acetyl-L-tyrosyl-L-valyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-alaninamide;N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone

AC-YVAD-CMK Structural

What is AC-YVAD-CMK?

The Uses of AC-YVAD-CMK

Ac-YVAD-CMK is a selective, irreversible inhibitor of interleukin-1β converting enzyme (ICE; Caspase-1). Ac-YVAD-CMK is neuroprotective in a rat model of cerebral ischemia.[Cayman Chemical]

The Uses of AC-YVAD-CMK

Ac-YVAD-cmk has been used:

  • as an inflammasome inhibitor to add to THP-1 cells or PBMC (peripheral blood mononuclear cell) before stimulation
  • as a caspase-1 inhibitor injected to C57BL/6 mice
  • as a caspase-1 inhibitor, administered into mice before and during hematopoietic stem cell transplantation (HSCT) to evaluate its effect on bone marrow inflammatory injury
  • to abolish the histidine-rich protein II (HRPII) effect on transendothelial electrical resistance (TEER)
  • as caspase 1 inhibitor, to treat MCF-7 tumor xenograft mice, to validate the role of inflammasomes activation in tumor growth?in vivo?condition

What are the applications of Application

Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5

General Description

Interleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. Caspase-1 inhibitor II is a cell-permeable, irreversible inhibitor of Caspase-1, Caspase-4, and Caspase-5. Inhibits CPP32/Apopain at a much higher concentration. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.

Biochem/physiol Actions

Ac-YVAD-cmk is a selective ireversible inhibitor of caspase-1 (interleukin-1β converting enzyme, ICE) with some activity also against caspase-4. Ac-YVAD-cmk is anti-apoptotic and has anti-inflammatory and neuroprotective effects, thought to result from its preventing caspase-1 activation of the proinflammatory cytokine, Interleukin-1β.

Properties of AC-YVAD-CMK

Melting point: >205°C (dec.)
RTECS  AY3079566
storage temp.  -20°C
solubility  DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form  White solid
color  white to off-white
Stability: Hygroscopic

Safety information for AC-YVAD-CMK

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for AC-YVAD-CMK

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