AC-YVAD-AFC
Synonym(s):Ac-YVAD-AFC;Caspase-1 Substrate VI, Fluorogenic - CAS 219137-85-6 - Calbiochem;Z-YVAD-AFC
- CAS NO.:219137-85-6
- Empirical Formula: C33H36F3N5O10
- Molecular Weight: 719.66
- MDL number: MFCD01318881
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:35
What is AC-YVAD-AFC?
Description
Ac-YVAD-AFC is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-
The Uses of AC-YVAD-AFC
N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.
What are the applications of Application
Ac-YVAD-AFC is a fluorogenic substrate for caspase-1 and caspase-4
Definition
ChEBI: Ac-Tyr-Val-Ala-Asp-7-amino-4-trifluoromethylcoumarin is a tetrapeptide obtained by formal condensation of the C-terminal carboxy group of Ac-Tyr-Val-Ala-Asp with the amino group of 7-amino-4-trifluoromethylcoumarin. It has a role as a protease inhibitor. It is a tetrapeptide, a member of acetamides, a member of coumarins and an organofluorine compound. It is functionally related to a 7-amino-4-(trifluoromethyl)coumarin.
Biological Activity
Fluorogenic peptide substrate for caspase-1 (ICE).
Properties of AC-YVAD-AFC
Melting point: | >190°C (dec.) |
Boiling point: | 1084.6±65.0 °C(Predicted) |
Density | 1.416±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | DMSO (Slightly), Methanol (Silghtly) |
form | powder |
pka | 4.09±0.10(Predicted) |
color | white |
Safety information for AC-YVAD-AFC
Computed Descriptors for AC-YVAD-AFC
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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