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HomeProduct name listAC-IETD-AFC

AC-IETD-AFC

AC-IETD-AFC Structural

What is AC-IETD-AFC?

The Uses of AC-IETD-AFC

Ac-IETD-AFC is a fluorogenic substrate for caspase-8/caspase-3 processing enzyme and granzyme B. It is also a substrate for caspase-10. The IETD sequence is based on caspase-3 proenzyme cleavage site.

The Uses of AC-IETD-AFC

N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-(trifluoromethyl)coumarin is a fluorogenic substrate for caspases -6, -8, and -10. The IETD sequence is based on the procaspase-3 cleavage site. Residues 172-175 of procaspase-3 are cleaved during apoptosis to produce the p12 subunit and a p20 peptide that is further cleaved to form the p17 subunit of mature caspase 3.

What are the applications of Application

Ac-IETD-AFC is a substrate for caspase-8/caspase-3 processing enzyme and granzyme B

Properties of AC-IETD-AFC

Boiling point: 1113.8±65.0 °C(Predicted)
Density  1.437±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in DMSO
form  Lyophilized powder
pka 4.09±0.10(Predicted)
color  White to off-white

Safety information for AC-IETD-AFC

Computed Descriptors for AC-IETD-AFC

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