Abacavir
- CAS NO.:783292-37-5
- Empirical Formula: C14H18N6O
- Molecular Weight: 286.33
- Update Date: 2022-12-21 16:56:50
What is Abacavir?
The Uses of Abacavir
(1R,?4R)?-?rel-4-?[2-Amino-?6-?(cyclopropylamino)?-?9H-?purin-?9-?yl]?-?2-?cyclopentene-?1-?methanol (Abacavir EP Impurity D) is an impurity of Abacavir A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Properties of Abacavir
Boiling point: | 636.0±65.0 °C(Predicted) |
Density | 1.70±0.1 g/cm3(Predicted) |
pka | 14.86±0.10(Predicted) |
Safety information for Abacavir
Computed Descriptors for Abacavir
New Products
Tubulysin H Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin G Tubulysin A 4,4-DIFLUOROCYCLOHEXANAMINE CYCLOBUTYLAMINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-Aminocyclobutanone hydrochloride 1-(1,1-Difluoroethyl)-2-fluorobenzene tetrahydro-4-methyl-2H-pyran 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Calcium Sodium Phosphosilicate IH Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
Abacavir sulfate
2-Amino-6-cyclopropylamino-9H-purine
Abacavir
Abacavir Related CoMpound D
(1S–4R)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
(1R,3S)-3-[2-AMino-6-(cyclopropylaMino)-9H-purin-9-yl]cyclopentaneMethanol
6-aminocarbovir
2,6-Diaminopurine
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