A[5']P5[5']A SODIUM SALT
- CAS NO.:4097-04-5
- Empirical Formula: C20H24N10Na5O22P5
- Molecular Weight: 1026.28
- MDL number: MFCD00077718
- EINECS: 223-852-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is A[5']P5[5']A SODIUM SALT?
The Uses of A[5']P5[5']A SODIUM SALT
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:
- an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
- mitochondrial lysates during ATP synthesis
- tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
- chromoplasts
General Description
P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions.
Biochem/physiol Actions
A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.
Properties of A[5']P5[5']A SODIUM SALT
storage temp. | -20°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white to white with yellow cast |
BRN | 4949216 |
Safety information for A[5']P5[5']A SODIUM SALT
Computed Descriptors for A[5']P5[5']A SODIUM SALT
New Products
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