9-Aminocamptothecin
- CAS NO.:91421-43-1
- Empirical Formula: C20H17N3O4
- Molecular Weight: 363.37
- MDL number: MFCD00909855
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is 9-Aminocamptothecin?
The Uses of 9-Aminocamptothecin
9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.
What are the applications of Application
9-Aminocamptothecin is an active derivative of camptothecin and topoisomerase inhibitor
Definition
ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.
Biological Activity
9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].
References
[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.
Properties of 9-Aminocamptothecin
Melting point: | 142.0-145.0 °C |
Boiling point: | 819.6±65.0 °C(Predicted) |
Density | 1.55±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C(protect from light) |
solubility | ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide |
form | powder to crystal |
pka | 11.23±0.20(Predicted) |
color | Light yellow to Yellow to Orange |
Merck | 14,431 |
CAS DataBase Reference | 91421-43-1(CAS DataBase Reference) |
Safety information for 9-Aminocamptothecin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 9-Aminocamptothecin
InChIKey | FUXVKZWTXQUGMW-FQEVSTJZSA-N |
New Products
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