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HomeProduct name list9-Aminocamptothecin

9-Aminocamptothecin

9-Aminocamptothecin Structural

What is 9-Aminocamptothecin?

The Uses of 9-Aminocamptothecin

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

What are the applications of Application

9-Aminocamptothecin is an active derivative of camptothecin and topoisomerase inhibitor

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

Properties of 9-Aminocamptothecin

Melting point: 142.0-145.0 °C
Boiling point: 819.6±65.0 °C(Predicted)
Density  1.55±0.1 g/cm3(Predicted)
storage temp.  2-8°C(protect from light)
solubility  ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form  powder to crystal
pka 11.23±0.20(Predicted)
color  Light yellow to Yellow to Orange
Merck  14,431
CAS DataBase Reference 91421-43-1(CAS DataBase Reference)

Safety information for 9-Aminocamptothecin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 9-Aminocamptothecin

InChIKey FUXVKZWTXQUGMW-FQEVSTJZSA-N

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