9-AMINOACRIDINE

Synonym(s):9-Acridinylamine, Aminacrine;9-Aminoacridine;Aminacrine

CAS NO.：90-45-9
Empirical Formula: C13H10N2
Molecular Weight: 194.23
MDL number: MFCD00037839
EINECS: 201-995-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is 9-AMINOACRIDINE?

Chemical properties

yellow crystals or powder

The Uses of 9-AMINOACRIDINE

Acridine analog. DNA intercalating agent.

The Uses of 9-AMINOACRIDINE

antibacterial

The Uses of 9-AMINOACRIDINE

A MALDI matrix exhibiting low background and good sensitivity in the analysis of low molecular weight anions, such as metabolites, in negative mode

What are the applications of Application

9-Aminoacridine free base is a mutagenic fluorescent dye and an intracellular pH indicator

Definition

ChEBI: An aminoacridine that is acridine in which the hydrogen at position 9 is replaced by an amino group. A fluorescent dyd and topical antiseptic agent, it is used (usually as the hydrochloride salt) in eye drops for the treatment of superficial eye infections

brand name

Monacrin (Sterling Winthrop).

General Description

Yellow needles. Free soluble in alcohol.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

9-AMINOACRIDINE is a moderately strong base. Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for 9-AMINOACRIDINE are not available; however, 9-AMINOACRIDINE is probably combustible.

Purification Methods

It crystallises from EtOH or acetone and sublimes at 170-180o/0.04mm [Albert & Ritchie Org Synth Coll Vol III 53 1955, for hydrochloride, see below]. [Beilstein 22 H 463, 21 II 280, 21 III/IV 4174.]

Properties of 9-AMINOACRIDINE

Melting point:	238-240℃
Boiling point:	320.68°C (rough estimate)
Density	1.268
refractive index	1.5014 (estimate)
storage temp.	Store below +30°C.
solubility	ethanol: hazy
form	Solid
pka	9.99(at 20℃)
color	Yellow
Water Solubility	11.65mg/L(24 ºC)
λmax	406nm(DMF)(lit.)
Merck	14,407
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	90-45-9(CAS DataBase Reference)
EPA Substance Registry System	9-Aminoacridine (90-45-9)

Safety information for 9-AMINOACRIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.