8-OXO-2'-DEOXYGUANOSINE

Synonym(s):8-Oxo-7,8-dihydro-2′-deoxyguanosine;8-Oxo-dG

CAS NO.：88847-89-6
Empirical Formula: C10H13N5O5
Molecular Weight: 283.24
MDL number: MFCD00210311
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-07 21:39:59

What is 8-OXO-2'-DEOXYGUANOSINE?

Description

8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3

Chemical properties

White Crystalline Solid

The Uses of 8-OXO-2'-DEOXYGUANOSINE

A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro

The Uses of 8-OXO-2'-DEOXYGUANOSINE

A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.

The Uses of 8-OXO-2'-DEOXYGUANOSINE

8-Hydroxy-2′-deoxyguanosine has been used:

as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
as a standard for LC/MS/MS analysis

What are the applications of Application

8-Hydroxy-2′-deoxyguanosine is a useful marker for indication of DNA damage via mutagenesis and carcinogenesis

Definition

ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

Biochem/physiol Actions

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

References

1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636 2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221 3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41

Properties of 8-OXO-2'-DEOXYGUANOSINE

Melting point:	217-220°C
Density	2.25±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO (up to 10 mg/ml).
form	White to off-white solid.
pka	7.86±0.20(Predicted)
color	Off-white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety information for 8-OXO-2'-DEOXYGUANOSINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.