8-M-PDOT
- CAS NO.：134865-70-6
- Empirical Formula: C14H19NO2
- Molecular Weight: 233.31
- MDL number: MFCD00901636
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 8-M-PDOT?
Description
8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.
The Uses of 8-M-PDOT
AH 002 is a selective melatonin receptor agonist.
What are the applications of Application
8-M-PDOT is a melatonin receptor agonist selective for MEL-1B-R subtype
Biological Activity
Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.
Properties of 8-M-PDOT
| Boiling point: | 447.8±45.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| form | Powder |
| pka | 15.87±0.20(Predicted) |
| color | White to off-white |
Safety information for 8-M-PDOT
Computed Descriptors for 8-M-PDOT
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