8-M-PDOT
- CAS NO.：134865-70-6
- Empirical Formula: C14H19NO2
- Molecular Weight: 233.31
- MDL number: MFCD00901636
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 8-M-PDOT?
Description
8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.
The Uses of 8-M-PDOT
AH 002 is a selective melatonin receptor agonist.
What are the applications of Application
8-M-PDOT is a melatonin receptor agonist selective for MEL-1B-R subtype
Biological Activity
Melatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.
Properties of 8-M-PDOT
| Boiling point: | 447.8±45.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| form | Powder |
| pka | 15.87±0.20(Predicted) |
| color | White to off-white |
Safety information for 8-M-PDOT
Computed Descriptors for 8-M-PDOT
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
You may like
-
88150-47-4 99%View Details
88150-47-4 -
VILDAGLIPTIN 274901-16-5 99%View Details
274901-16-5 -
177-11-7 1,4-Dioxa-8-azaspiro[4.5]decane 98+View Details
177-11-7 -
217299-03-1 98+View Details
217299-03-1 -
(R)-3-Aminobutanenitrile Hydrochloride 98+View Details
1073666-55-3 -
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 39124-20-4 98+View Details
39124-20-4 -
2006278-26-6 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 98+View Details
2006278-26-6 -
39856-50-3 98+View Details
39856-50-3
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.