8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE

Synonym(s):1,3-Dipropyl-8-cyclopentylxanthine;DPCPX;PD 116,948

CAS NO.：102146-07-6
Empirical Formula: C16H24N4O2
Molecular Weight: 304.39
MDL number: MFCD00055117
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Structural

What is 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE?

Chemical properties

White Solid

The Uses of 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE

8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages and human umbilical vein endothelial cells (HUVECs). It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect.

The Uses of 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE

DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist

What are the applications of Application

PD 116,948 is a very potent and selective Adenosine A1-R antagonist

Definition

ChEBI: An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.

Biological Activity

Potent and selective A 1 adenosine receptor antagonist, both in vitro and in vivo . K i values are 3.9, 130, 50 and 4000 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively.

Biochem/physiol Actions

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1?adenosine receptor antagonist. DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases.

storage

Room temperature

Properties of 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE

Melting point:	178°C
Boiling point:	535.1±42.0 °C(Predicted)
Density	1.195±0.06 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO: >10 mg/mL
form	solid
pka	9.01±0.70(Predicted)
color	white
Stability:	Store tightly sealed at RT; Solutions at 4 deg C for several days
CAS DataBase Reference	102146-07-6(CAS DataBase Reference)

Safety information for 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.