8-BROMOADENOSINE

Synonym(s):6-Amino-8-bromopurine riboside;8-Bromoadenine-9-β-D-ribofuranoside

CAS NO.：2946-39-6
Empirical Formula: C10H12BrN5O4
Molecular Weight: 346.14
MDL number: MFCD00005733
EINECS: 220-959-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is 8-BROMOADENOSINE?

Description

8-Bromoadenosine is a nucleotide that is structurally related to adenosine. It can be used as an inhibitor of guanine nucleotide-binding proteins and has shown biological properties in vitro. 8-Bromoadenosine has been shown to inhibit the mitochondrial membrane potential, cytosolic Ca2+, and the synthesis of RNA and protein. 8-Bromoadenosine also inhibits leukemia inhibitory factor (LIF) production by 3T3-L1 preadipocytes and induces apoptosis in T84 cells.

Chemical properties

Off-White Solid

The Uses of 8-BROMOADENOSINE

8-Bromoadenosine is an adenosine binding inhibitor. formation of 8-S-L-cysteinyladenosine from 8-Bromoadenosine and cysteine.

What are the applications of Application

8-Bromoadenosine is an adenosine binding inhibitor

Definition

ChEBI: 8-Bromoadenosine is a purine nucleoside.

Properties of 8-BROMOADENOSINE

Melting point:	210-212 °C (dec.)(lit.)
Boiling point:	717.7±70.0 °C(Predicted)
Density	1.8171 (rough estimate)
refractive index	1.6400 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	powder
pka	12.89±0.70(Predicted)
color	white
Water Solubility	Soluble in DMSO, and DMF. Insoluble in water.
Sensitive	Air Sensitive
BRN	627737
CAS DataBase Reference	2946-39-6(CAS DataBase Reference)

Safety information for 8-BROMOADENOSINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.