8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
Synonym(s):8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
- CAS NO.：264622-58-4
- Empirical Formula: C26H26N6O4
- Molecular Weight: 486.52
- MDL number: MFCD09971130
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
![8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate Structural](https://img.chemicalbook.in/CAS/GIF/264622-58-4.gif)
What is 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate?
The Uses of 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
MRS 1754 acts as an adenosine receptor antagonist which displays bronchospasmolytic activity, applicable to treatments involving respiratory disorders.
Definition
ChEBI: N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide is an oxopurine.
Biological Activity
Selective adenosine A 2B receptor antagonist (K i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA 2B , rA 1 , hA 1 , hA 2A , hA 3 and rA 2A receptors respectively).
Biochem/physiol Actions
MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.
storage
Desiccate at RT
Properties of 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble >10mg/mL |
| pka | 8.24±0.70(Predicted) |
| form | solid |
| color | off-white |
Safety information for 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H290:Corrosive to Metals H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P390:Absorb spillage to prevent material damage. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner. |
Computed Descriptors for 8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
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