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HomeProduct name list7-Nitroindole

7-Nitroindole

Synonym(s):NSC 69874

  • CAS NO.:6960-42-5
  • Empirical Formula: C8H6N2O2
  • Molecular Weight: 162.15
  • MDL number: MFCD00005683
  • EINECS: 677-504-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-05-24 15:44:31
7-Nitroindole Structural

What is 7-Nitroindole?

Chemical properties

yellow crystalline powder

The Uses of 7-Nitroindole

7-Nitroindole is a reagent used in chemical synthesis. It has been used in the synthesis of protein kinase and inosine monophosphate inhibitors, beta3 agonists and CCK-1 receptor modulators. 7-Nitroindole has also been used as a photochemical precursor of the 2'-deoxyribonolactone analog.

The Uses of 7-Nitroindole

7-Nitroindole is a useful reactant for the preparation of various compounds and inhibitors.

The Uses of 7-Nitroindole

Reactant for preparation of:

  • Protein kinase inhibitors
  • Potential fructose 1,6-bisphosphatase inhibitors
  • Factor Xa inhibitors
  • Antagonist of the mineralocorticoid receptor
  • Antitumor sulfonamides
  • Inosine monophosphate dehydrogenase (IMPDH) inhibitors
  • Subtype-selective cyclooxygenase (COX) inhibitors
  • Thrombin protease-activated receptor (PAR-1) ligands

What are the applications of Application

7-Nitroindole is 7-Nitroindole is a reactant for preparation of protein kinase inhibitors, Factor Xa inhibitors, subtype-selective cyclooxygenase (COX) inhibitors, and Thrombin protease-activated receptor (PAR-1) ligands.

What are the applications of Application

Reactant for preparation of:
Protein kinase inhibitors
Potential fructose 1,6-bisphosphatase inhibitors
Factor Xa inhibitors
Antagonist of the mineralocorticoid receptor
Antitumor sulfonamides
Inosine monophosphate dehydrogenase (IMPDH) inhibitors
Subtype-selective cyclooxygenase (COX) inhibitors
Thrombin protease-activated receptor (PAR-1) ligands

Synthesis Reference(s)

Canadian Journal of Chemistry, 42, p. 1235, 1964 DOI: 10.1139/v64-189

Properties of 7-Nitroindole

Melting point: 94-98 °C (lit.)
Boiling point: 288.82°C (rough estimate)
Density  1.3264 (rough estimate)
refractive index  1.5770 (estimate)
storage temp.  Sealed in dry,Room Temperature
pka 13.96±0.30(Predicted)
form  powder to crystal
color  Light yellow to Yellow to Orange
Water Solubility  slightly soluble
BRN  130874
CAS DataBase Reference 6960-42-5(CAS DataBase Reference)

Safety information for 7-Nitroindole

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.

Computed Descriptors for 7-Nitroindole

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