7-HYDROXYFLAVONE

Synonym(s):7-Hydroxy-2-phenyl-4H-1-benzopyran-4-one;NSC 94258

CAS NO.：6665-86-7
Empirical Formula: C15H10O3
Molecular Weight: 238.24
MDL number: MFCD00006835
EINECS: 229-705-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-08-17 16:10:33

What is 7-HYDROXYFLAVONE?

Chemical properties

off-white crystals

The Uses of 7-HYDROXYFLAVONE

antifungal, analgesic

The Uses of 7-HYDROXYFLAVONE

Reactant:

Acting as a biologically valuable acceptor in O-glycosidation reactions
Involved in synthesis of fully phosphorylated flavones for use as pancreatic cholesterol esterase inhibitors
For O-methylation with di-Me carbonate
Linked by a polymethylene chain for synthesis of α1-adrenoceptor antagonists
Involved in Baylis-Hillman reactions
Involved in phase-transfer catalyzed glucosylation for synthesis of glucosylated flavonoids

What are the applications of Application

7-Hydroxyflavone is involved in synthesis of fully phosphorylated flavones

Definition

ChEBI: 7-hydroxyflavone is a hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4

Biological Activity

7-Hydroxyflavone is a flavonoid isolated from M. indica with anti-inflammatory properties. It protects renal cells from nicotine (NIC)-induced cytotoxicity through the ERK/Nrf2/HO-1 pathway.

Properties of 7-HYDROXYFLAVONE

Melting point:	245-247 °C (lit.)
Boiling point:	320.83°C (rough estimate)
Density	1.340±0.06 g/cm3 (20 ºC 760 Torr)
refractive index	1.5740 (estimate)
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Water Solubility	Insoluble in water
pka	7.02±0.40(Predicted)
form	powder to crystal
color	White to Light yellow
BRN	194089
CAS DataBase Reference	6665-86-7(CAS DataBase Reference)

Safety information for 7-HYDROXYFLAVONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.