7-HYDROXYFLAVONE

Chemical properties

off-white crystals

The Uses of 7-HYDROXYFLAVONE

antifungal, analgesic

The Uses of 7-HYDROXYFLAVONE

Reactant:

• Acting as a biologically valuable acceptor in O-glycosidation reactions
• Involved in synthesis of fully phosphorylated flavones for use as pancreatic cholesterol esterase inhibitors
• For O-methylation with di-Me carbonate
• Linked by a polymethylene chain for synthesis of α1-adrenoceptor antagonists
• Involved in Baylis-Hillman reactions
• Involved in phase-transfer catalyzed glucosylation for synthesis of glucosylated flavonoids

What are the applications of Application

7-Hydroxyflavone is involved in synthesis of fully phosphorylated flavones

Definition

ChEBI: 7-hydroxyflavone is a hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 6497, 1990 DOI: 10.1016/S0040-4039(00)97100-4

Biological Activity

7-Hydroxyflavone is a flavonoid isolated from M. indica with anti-inflammatory properties. It protects renal cells from nicotine (NIC)-induced cytotoxicity through the ERK/Nrf2/HO-1 pathway.