7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Synonym(s):Avantrin;N,N-diethyl-5-methyl-[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine;Rocornal;Trapymin;Trapymine

CAS NO.：15421-84-8
Empirical Formula: C10H15N5
Molecular Weight: 205.26
MDL number: MFCD00193104
EINECS: 239-434-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Structural

What is 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE?

Chemical properties

White or almost white, crystalline powder

Originator

Rocornal,Mochida,Japan,1978

The Uses of 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Vasodilator;PDGF antagonist

Definition

ChEBI: Trapidil is a member of triazolopyrimidines.

Manufacturing Process

8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.

Therapeutic Function

Coronary vasodilator

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

Properties of 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Melting point:	98-99.4° (Pfeifer); 102-104° from heptane (Tenor)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	H2O: ≥15mg/mL
form	powder
pka	pKs = 2.79(at 25℃)
color	white to tan
CAS DataBase Reference	15421-84-8

Safety information for 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.