7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
Synonym(s):Avantrin;N,N-diethyl-5-methyl-[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine;Rocornal;Trapymin;Trapymine
- CAS NO.：15421-84-8
- Empirical Formula: C10H15N5
- Molecular Weight: 205.26
- MDL number: MFCD00193104
- EINECS: 239-434-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
![7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Structural](https://img.chemicalbook.in/CAS/GIF/15421-84-8.gif)
What is 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE?
Chemical properties
White or almost white, crystalline powder
Originator
Rocornal,Mochida,Japan,1978
The Uses of 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
Vasodilator;PDGF antagonist
Definition
ChEBI: Trapidil is a member of triazolopyrimidines.
Manufacturing Process
8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.
Therapeutic Function
Coronary vasodilator
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.
Properties of 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
| Melting point: | 98-99.4° (Pfeifer); 102-104° from heptane (Tenor) |
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: ≥15mg/mL |
| form | powder |
| pka | pKs = 2.79(at 25℃) |
| color | white to tan |
| CAS DataBase Reference | 15421-84-8 |
Safety information for 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 4-Hydrazinobenzoic acid 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 3-NITRO-2-METHYL ANILINE 4-IODO BENZOIC ACID 4-HYDROXY BENZYL ALCOHOL 4-(3-chloropropyl)morpholine phenylhydrazine hydrochloride (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 4-methoxy-3,5-dinitropyridine 2-(Cyanocyclohexyl)acetic acid 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride tert-butyl 4- (ureidomethyl)benzylcarbamateRelated products of tetrahydrofuran
![8-(4-METHOXYBENZYL)-5-METHYL-7,8-DIHYDRO-6H-PYRROLO[3,2-E][1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE](https://img.chemicalbook.in/StructureFile/ChemBookStructure6/GIF/CB1307689.gif)
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