7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

CAS NO.：62252-26-0
Empirical Formula: C10H8ClNO3
Molecular Weight: 225.63
MDL number: MFCD04035584
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN?

The Uses of 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

Definition

ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.

Biological Activity

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

References

[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.

Properties of 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

Melting point:	115 °C
Boiling point:	456.1±45.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Slightly)
form	Solid
pka	1.95±0.20(Predicted)
color	Yellow to Beige
Stability:	Hygroscopic

Safety information for 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.