7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
- CAS NO.:62252-26-0
- Empirical Formula: C10H8ClNO3
- Molecular Weight: 225.63
- MDL number: MFCD04035584
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-12 15:22:20
What is 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN?
The Uses of 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.
Definition
ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.
Biological Activity
Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .
References
[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.
Properties of 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Melting point: | 115 °C |
Boiling point: | 456.1±45.0 °C(Predicted) |
Density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | DMSO (Slightly) |
form | Solid |
pka | 1.95±0.20(Predicted) |
color | Yellow to Beige |
Stability: | Hygroscopic |
Safety information for 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P362:Take off contaminated clothing and wash before reuse. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
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