6-THIOGUANOSINE
- CAS NO.：85-31-4
- Empirical Formula: C10H13N5O4S
- Molecular Weight: 299.31
- MDL number: MFCD00005736
- EINECS: 201-597-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 19:41:26
What is 6-THIOGUANOSINE?
Chemical properties
Tan Powder
The Uses of 6-THIOGUANOSINE
antineoplastic
Definition
ChEBI: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-3H-purine-6-thione is a purine nucleoside.
Purification Methods
Thioguanosine is crystallised (as hemihydrate) from hot H2O (charcoal) and cooled slowly to give tapered prisms. It also crystallises by dissolving in dilute NH3 and acidifying with acetic acid, and then recrystallising from H2O. UV: (pH 4-6) max at 257nm ( 8,820) and 342nm ( 24,800), and (pH 10.4-12.0) max at 252nm ( 14,700) and 319.5nm ( 21,000). [Fox et al. J Am Chem Soc 80 1667 1958, Beilstein 26 III/IV 3927.]
Properties of 6-THIOGUANOSINE
| Melting point: | 230-231°C |
| Boiling point: | 756.9±70.0 °C(Predicted) |
| Density | 2.18 |
| refractive index | 1.6460 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| pka | 13.21±0.70(Predicted) |
| form | Solid |
| color | Off-white to light yellow |
| CAS DataBase Reference | 85-31-4(CAS DataBase Reference) |
Safety information for 6-THIOGUANOSINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-THIOGUANOSINE
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