6-PHENYL-3(2H)-PYRIDAZINONE

CAS NO.：2166-31-6
Empirical Formula: C10H8N2O
Molecular Weight: 172.18
MDL number: MFCD00114953
EINECS: 218-505-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

What is 6-PHENYL-3(2H)-PYRIDAZINONE?

The Uses of 6-PHENYL-3(2H)-PYRIDAZINONE

6-Phenylpyridazin-3(2H)-one is a reagent in the preparation of cyclase activator Runcaciguat, a compound used in the treatment of kidney disease and non-proliferative diabetic retinopathy.

General Description

6-Phenyl-3(2H)-pyridazinone is a pyridazinone derivative that can be prepared from 4,5- dihydro-6-phenyl-3(2H)-pyridazinone. It is reported to be a weak positive inotropic agent. 6-Phenyl-3(2H)-pyridazinone forms the core of compounds that show a potential antiplatelet activity.

Properties of 6-PHENYL-3(2H)-PYRIDAZINONE

Melting point:	201-204 °C(lit.)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	11.05±0.40(Predicted)
color	White to Light yellow
λmax	249nm(HCl aq.)(lit.)

Safety information for 6-PHENYL-3(2H)-PYRIDAZINONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.