6-NITROVERATRYL CHLOROFORMATE

Synonym(s):6-Nitroveratryl chloroformate;6-Nitroveratryloxycarbonyl chloride;NVOC chloride;NVOC-Cl

CAS NO.：42855-00-5
Empirical Formula: C10H10ClNO6
Molecular Weight: 275.64
MDL number: MFCD00143507
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

6-NITROVERATRYL CHLOROFORMATE Structural

What is 6-NITROVERATRYL CHLOROFORMATE?

The Uses of 6-NITROVERATRYL CHLOROFORMATE

4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

The Uses of 6-NITROVERATRYL CHLOROFORMATE

4,5-Dimethoxy-2-nitrobenzyl chloroformate (NVOC-Cl) is a photolabile protecting reagent, commonly used in peptide or nucleotide synthesis to protect amines and hydroxyl groups. General applications are:

Preparation of inactive, caged protein conjugates which can be activated by irradiating near-ultraviolet light.
Solid-phase synthesis of base-sensitive S-acylthioethyl (SATE)-prooligonucleotides.
Modification of surface properties by introducing photocleavable NVOC moiety into chitosan to control cell attachment.

Properties of 6-NITROVERATRYL CHLOROFORMATE

Melting point:	125 °C (dec.)(lit.)
Boiling point:	396.4±42.0 °C(Predicted)
Density	1.399±0.06 g/cm3(Predicted)
storage temp.	2-8°C
color	Pale yellow
Water Solubility	Soluble in methanol, acetone. Reacts with water.
Sensitive	Moisture & Light Sensitive
BRN	2389168

Safety information for 6-NITROVERATRYL CHLOROFORMATE

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.