6-NITROVERATRYL CHLOROFORMATE
Synonym(s):6-Nitroveratryl chloroformate;6-Nitroveratryloxycarbonyl chloride;NVOC chloride;NVOC-Cl
- CAS NO.：42855-00-5
- Empirical Formula: C10H10ClNO6
- Molecular Weight: 275.64
- MDL number: MFCD00143507
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 6-NITROVERATRYL CHLOROFORMATE?
The Uses of 6-NITROVERATRYL CHLOROFORMATE
4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.
The Uses of 6-NITROVERATRYL CHLOROFORMATE
4,5-Dimethoxy-2-nitrobenzyl chloroformate (NVOC-Cl) is a photolabile protecting reagent, commonly used in peptide or nucleotide synthesis to protect amines and hydroxyl groups. General applications are:
- Preparation of inactive, caged protein conjugates which can be activated by irradiating near-ultraviolet light.
- Solid-phase synthesis of base-sensitive S-acylthioethyl (SATE)-prooligonucleotides.
- Modification of surface properties by introducing photocleavable NVOC moiety into chitosan to control cell attachment.
Properties of 6-NITROVERATRYL CHLOROFORMATE
| Melting point: | 125 °C (dec.)(lit.) |
| Boiling point: | 396.4±42.0 °C(Predicted) |
| Density | 1.399±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| color | Pale yellow |
| Water Solubility | Soluble in methanol, acetone. Reacts with water. |
| Sensitive | Moisture & Light Sensitive |
| BRN | 2389168 |
Safety information for 6-NITROVERATRYL CHLOROFORMATE
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-NITROVERATRYL CHLOROFORMATE
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