6-HYDROXYFLAVANONE

CAS NO.：4250-77-5
Empirical Formula: C15H12O3
Molecular Weight: 240.25
MDL number: MFCD00017485
EINECS: 624-472-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 20:01:59

What is 6-HYDROXYFLAVANONE?

Chemical properties

Slightly yellow-cream powder

The Uses of 6-HYDROXYFLAVANONE

6-Hydroxyflavanone (6-HF) has been used for the enantiomeric separation of flavonoids using polysaccharide-based chiral stationary phases by nano-liquid chromatography (nano-LC). Racemic 6-HF may be used in the synthesis of 6-propionoxy-flavanone (6-PF). 6-HF may be employed as synthetic flavone to investigate the mechanism of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced cytotoxic and apoptotic effects in HeLa cancer cells.

What are the applications of Application

6-Hydroxyflavanone is a useful biochemical flavonoid for proteomics research

Definition

ChEBI: A monohydroxyflavanone that is flavanone substituted by a hydroxy group at position 6.

General Description

6-Hydroxyflavanone is a flavonoid. Its biotransformation by Aspergillus niger strains have been described. Crystal structure of S and R enanti-omers of 6-hydroxyflavanone has been reported to have four crystallographic sites of the unit cell in an approximate 3:1/1:3 ratio. It was identified as a metabolite of flavnone on incubation with rat liver microsomes by positive ion electrospray LC/MS analysis.

Properties of 6-HYDROXYFLAVANONE

Melting point:	220-222 °C (dec.) (lit.)
Boiling point:	464.3±45.0 °C(Predicted)
Density	1.288±0.06 g/cm3(Predicted)
form	powder to crystal
pka	9.53±0.40(Predicted)
color	White to Orange to Green
BRN	87354
CAS DataBase Reference	4250-77-5(CAS DataBase Reference)

Safety information for 6-HYDROXYFLAVANONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.