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HomeProduct name list6-HYDROXY-7-METHOXYCOUMARIN

6-HYDROXY-7-METHOXYCOUMARIN

Synonym(s):6-Hydroxy-7-methoxycoumarin;7-Methoxyesculetin;Esculetin 7-methyl ether;Isoscopoletin

  • CAS NO.:776-86-3
  • Empirical Formula: C10H8O4
  • Molecular Weight: 192.17
  • MDL number: MFCD00016976
  • EINECS: 212-282-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-25 18:01:00
6-HYDROXY-7-METHOXYCOUMARIN Structural

What is 6-HYDROXY-7-METHOXYCOUMARIN?

Description

Isoscopolamine is an antiasthmatic drug, which has the effect of relaxing smooth muscle and antihistamine. It can be used clinically in patients with chronic bronchitis and bronchial asthma.

Chemical properties

Yellow needle-like crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Dengzhanhua, Rhododendron.

The Uses of 6-HYDROXY-7-METHOXYCOUMARIN

Isoscopolamine has anti-inflammatory, antioxidant, improving myocardial ischemia, anti-arrhythmic effects.

Definition

ChEBI: Isoscopoletin is a hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. It has a role as a plant metabolite. It is a hydroxycoumarin and an aromatic ether. It is functionally related to an esculetin.

Biological Activity

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active ingredient in Artemisia argyi. It has a significant inhibitory effect on cell proliferation with IC50 values of 4.0 μM and 1.6 μM against human CCRF-CEM leukemia cells and drug-resistant subline CEM/ADR5000, respectively. It (6-Hydroxy-7-methoxycoumarin) has the activity of inhibiting HBV replication.

Properties of 6-HYDROXY-7-METHOXYCOUMARIN

Melting point: 206-208°C
Boiling point: 413.5±45.0 °C(Predicted)
Density  1.37 g/cm3
storage temp.  Sealed in dry,2-8°C
solubility  DMSO: soluble
pka 8.94±0.20(Predicted)
form  Solid
color  Pale Beige to Light Beige
CAS DataBase Reference 776-86-3

Safety information for 6-HYDROXY-7-METHOXYCOUMARIN

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P330:Rinse mouth.
P363:Wash contaminated clothing before reuse.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P501:Dispose of contents/container to..…

Computed Descriptors for 6-HYDROXY-7-METHOXYCOUMARIN

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