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HomeProduct name list6-CHLOROQUINOLINE

6-CHLOROQUINOLINE

  • CAS NO.:612-57-7
  • Empirical Formula: C9H6ClN
  • Molecular Weight: 163.6
  • MDL number: MFCD00024024
  • EINECS: 210-314-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 14:09:54
6-CHLOROQUINOLINE Structural

What is 6-CHLOROQUINOLINE?

Chemical properties

beige to brown crystals

The Uses of 6-CHLOROQUINOLINE

6-chloroquinoline is a useful research chemical.

The Uses of 6-CHLOROQUINOLINE

6-Chloroquinoline may be used in the synthesis of 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine. It may be used as catalyst for high yield preparation of ethoxycarbonyl isothiocyanate.

Preparation

All the reactions were carried out in a 50 mL stainless steel autoclave . A mixture of glycerol (1 g, 1 equiv.), aniline (0.58 g, 0.5 equiv.), water (2.5 mL) and W-KIT-6 (100 mg) was charged in to the autoclave simultaneously and finally heated to 200 °C with stirring for 3 h. On completion of the reaction (monitored by TLC), the autoclave was cooled to room temperature and the catalyst was removed by filtration. Ethyl acetate (10 mL) and water (5 mL) were added to the reaction mixture and stirred well for few minutes. The organic layer was dried over anhydrous Na2SO4 and the crude was purified by column chromatography using 60-120 mesh silica with ethylacetate/hexane as eluent to afford 6-chloroquinoline in good yield.

General Description

The standard molar enthalpy of formation of 6-chloroquinoline has been derived from the standard molar enthalpy of combustion and was evaluated in terms of molecular structure. Its arylation reaction with diamine derivatives of adamantanes in the presence of palladium catalyst has been reported to afford N,N′-diaryl derivatives.

Properties of 6-CHLOROQUINOLINE

Melting point: 41-43 °C (lit.)
Boiling point: 126-127 °C/10 mmHg (lit.)
Density  1.2108 (rough estimate)
refractive index  1.6110 (estimate)
Flash point: >230 °F
storage temp.  Inert atmosphere,Room Temperature
pka 4.18±0.10(Predicted)
form  powder to lump
color  White to Light yellow to Light orange
Water Solubility  Insoluble in water.
BRN  112963
CAS DataBase Reference 612-57-7(CAS DataBase Reference)
NIST Chemistry Reference Quinoline, 6-chloro-,(612-57-7)
EPA Substance Registry System Quinoline, 6-chloro- (612-57-7)

Safety information for 6-CHLOROQUINOLINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-CHLOROQUINOLINE

InChIKey GKJSZXGYFJBYRQ-UHFFFAOYSA-N

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