6-Chloropurine riboside

Synonym(s):6-Chloropurine-9-β-D-ribofuranoside

CAS NO.：5399-87-1
Empirical Formula: C10H11ClN4O4
Molecular Weight: 286.67
MDL number: MFCD00005738
EINECS: 226-438-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is 6-Chloropurine riboside?

Chemical properties

Colourless Crystalline Powder

The Uses of 6-Chloropurine riboside

6-Chloropurine riboside is used to study the kinetics and substrate specificity of adenosine deaminase. 6-Chloropurine riboside is benzoylated to facilitate synthesis of nucleoside derivatives such as 9-(2,3-Di-deoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine. It , especially after phosphorylation to NMP, NDP or NTP, is used as a purine substrate analogue in studies with enzymes such as Inosine monophosphate dehydrogenase (IMPDH); bacteriophage T4 RNA-ligase (EC 6.5.1.3) and pancreatic fibonuclease A.

The Uses of 6-Chloropurine riboside

A substrate for adenosine deaminase

The Uses of 6-Chloropurine riboside

6-Chloropurine riboside is used to study the kinetics and substrate specificity of adenosine deaminase. 6-Chloropurine riboside is benzoylated to facilitate synthesis of nucleoside derivatives such as 9-(2,3-Di-deoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine. 6-Chloropurine riboside, especially after phosphorylation to NMP, NDP or NTP, is used as a purine substrate analogue in studies with enzymes such as Inosine monophosphate dehydrogenase (IMPDH); bacteriophage T4 RNA-ligase (EC 6.5.1.3) and pancreatic fibonuclease A.

Properties of 6-Chloropurine riboside

Melting point:	158-162 °C (dec.) (lit.)
Boiling point:	614.8±65.0 °C(Predicted)
Density	2.03±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Sparingly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated,
form	Powder
pka	13.06±0.70(Predicted)
color	White to slightly yellow
Water Solubility	Soluble in water. (10.6 mg/mL)
BRN	40573
CAS DataBase Reference	5399-87-1(CAS DataBase Reference)

Safety information for 6-Chloropurine riboside

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.