6-Chloropurine ribonucleoside

CAS NO.：2004-06-0
Empirical Formula: C10H11ClN4O4
Molecular Weight: 286.67
MDL number: MFCD00005738
EINECS: 217-904-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-08-22 13:52:55

What is 6-Chloropurine ribonucleoside?

Chemical properties

white to light yellow crystal powde

The Uses of 6-Chloropurine ribonucleoside

6-CHLOROPURINE RIBOSIDE acts as a reactant in the synthesis of isozyme-specific enzyme inhibitors as well as in the preparation of dog coronary artery receptor agonists.

Purification Methods

Purify the riboside by suspending the dry solid (~12 g) in hot MeOH (130 mL) and then adding enough hot H2O (~560mL) to cause solution, filter and set aside at 5o overnight. The colourless crystals of the riboside are filtered off, washed with Me2CO, Et2O and dried at 60o/0.1mm. More material can be obtained by evaporating the filtrate to dryness and recrystallisation of the residue from MeOH/H2O (2:1) (15mL/g). It has max 264nm ( 9140) in H2O. [Robins Biochemical Preparations 10 145 1963, Baker et al. J Org Chem 22 954 1957.]

Properties of 6-Chloropurine ribonucleoside

Melting point:	158-162 °C (dec.)(lit.)
Boiling point:	614.8±65.0 °C(Predicted)
Density	1.7303 (rough estimate)
refractive index	-45 ° (C=0.8, H2O)
storage temp.	Sealed in dry,Store in freezer, under -20°C
form	Powder
pka	13.06±0.70(Predicted)
color	Yellow to Green
CAS DataBase Reference	2004-06-0(CAS DataBase Reference)

Safety information for 6-Chloropurine ribonucleoside

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.