6-Bromoquinoline
- CAS NO.:5332-25-2
- Empirical Formula: C9H6BrN
- Molecular Weight: 208.05
- MDL number: MFCD00024023
- EINECS: 226-238-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-02 18:23:59
What is 6-Bromoquinoline?
Chemical properties
Thick Oil
The Uses of 6-Bromoquinoline
6-Bromoquinoline is used as fine chemical and pharmaceutical intermediate, used as the coupling reagent.
Synthesis
4-Bromobenzenamine (25 g, 145.32 mmol, 1.00 equiv), sodium 3-nitrobenzenesulfonate (55.5 g, 246.64 mmol, 1.70 equiv), propane-1,2,3-triol (50.8 g, 551.63 mmol, 3.80 equiv), and sulfuric acid (170 mL, 70%) were placed into a 500-mL round-bottom flask. The resulting solution was stirred overnight at 140° C. The pH value of the solution was adjusted to with 10% aqueous sodium hydroxide. The resulting solution was extracted with 5*150 mL of ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with ethyl acetate/petroleum ether (1:50). This resulted in 17.2 g (42%) of 6-bromoquinoline as yellow oil.
Properties of 6-Bromoquinoline
Melting point: | 19°C |
Boiling point: | 116 °C / 6mmHg |
Density | 1.538 g/mL at 25 °C |
refractive index | n20/D 1.663 |
Flash point: | 19 °C |
storage temp. | Inert atmosphere,2-8°C |
solubility | Soluble in acetone, acetonitrile, dichloromethane, ethyl acetate and THF. |
form | Oil |
pka | 4.18±0.10(Predicted) |
color | Light yellow to brown |
color | Thick |
CAS DataBase Reference | 5332-25-2(CAS DataBase Reference) |
NIST Chemistry Reference | 6-Bromo quinoline(5332-25-2) |
EPA Substance Registry System | Quinoline, 6-bromo- (5332-25-2) |
Safety information for 6-Bromoquinoline
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Bromoquinoline
InChIKey | IFIHYLCUKYCKRH-UHFFFAOYSA-N |
Abamectin manufacturer
REDDY N REDDY PHARMACEUTICALS
Dr R R Organics
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