6-BROMO-2,4-DICHLOROQUINAZOLINE
- CAS NO.:102393-82-8
- Empirical Formula: C8H3BrCl2N2
- Molecular Weight: 277.93
- MDL number: MFCD09744007
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-04 08:47:26
What is 6-BROMO-2,4-DICHLOROQUINAZOLINE?
The Uses of 6-BROMO-2,4-DICHLOROQUINAZOLINE
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
The synthesis of 6-BROMO-2,4-DICHLOROQUINAZOLINE is as follows:BTC (0.65 g, 2.2 mmol in 6mL of PhCl) was added to astirred solution of tris(4-methoxyphenyl)phosphine oxide 3d(0.33 g, 0.9 mmol in 5mL PhCl) dropwise in a round botttomflask placed on an ice bath. After complete addition,the mixture was stirred for 30 min at room temperature.Then isatin-3-oximes (3 mmol) were added, and the mixturewas heated to 120 C until completion of the reaction(followed by TLC, n-hexane/ethyl acetate 10:1). Aftercooling, the mixture was then poured into 50mL ice waterand extracted with ethyl acetate (320 mL). The organiclayer was dried over anhydrous Na2SO4 and concentrated invacuo. The crude product was purified over column chromatography(n-hexane/ethyl acetate 10:1) to afford thepure produce 2,4-dichloroquinazolins. Tris(4-methoxyphenyl)phosphine oxide 3d was recovered by column chromatography(n-hexane/ethyl acetate 1:1).
Properties of 6-BROMO-2,4-DICHLOROQUINAZOLINE
Boiling point: | 330.2±24.0 °C(Predicted) |
Density | 1.851±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
pka | -1.19±0.30(Predicted) |
form | Solid |
color | Off-white |
Water Solubility | Slightly soluble in water. |
InChI | InChI=1S/C8H3BrCl2N2/c9-4-1-2-6-5(3-4)7(10)13-8(11)12-6/h1-3H |
Safety information for 6-BROMO-2,4-DICHLOROQUINAZOLINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 6-BROMO-2,4-DICHLOROQUINAZOLINE
InChIKey | LBAYOWRVZAKPLS-UHFFFAOYSA-N |
SMILES | N1=C2C(C=C(Br)C=C2)=C(Cl)N=C1Cl |
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