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HomeProduct name list6-Aminofluorescein

6-Aminofluorescein

Synonym(s):Fluoresceinamine isomer II

  • CAS NO.:51649-83-3
  • Empirical Formula: C20H13NO5
  • Molecular Weight: 347.32
  • MDL number: MFCD00005051
  • EINECS: 257-334-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
6-Aminofluorescein Structural

What is 6-Aminofluorescein?

Description

6-Aminofluorescein (6-AF) is a new fluorescence dye with bright colors and high fluorescence intensity. Its chemical structure history contains a nitrogen group and a fluorescent group. The presence of the fluorescent component enables 6-Aminofluorescein to emit a distinct fluorescent signal when excited, making it valuable for fluorescent labeling and imaging. It is widely used in biological science research, chemical analysis and fluorescence microscopy.

Chemical properties

Yellow Solid

The Uses of 6-Aminofluorescein

Glycosaminoglycuronans react with 6-aminofluorescein to yield fluorescent derivatives.

The Uses of 6-Aminofluorescein

Fluorescent labeling reagent for proteins. Glycosaminoglycuronans react with 6-aminofluorescein to yield fluorescent derivatives. Used in the fluorescent antibody technique for rapid identification of pathogens.

What are the applications of Application

6-Aminofluorescein is a fluorescent labeling reagent for proteins

Biological Functions

6-Aminofluorescein has been demonstrated to be useful fluorescent labeling reagent for fullerene-based liposome nanostructures termed "buckysomes". 6-aminofluorescein dissolved in 0.1 N NaOH can be quantified from a maximum absorbance at 490 nm. Decarboxylated 6-aminofluorescein dissolved 6 N HCl (prepare by constant boiling at 110° C for 24 h) can be quantified from a maximum absorbance at 454 nm. Aldehyde groups are formed by oxidateive damage to proteins, which can be detected by conjugation to decarboxylated 6-aminofluorescein. 6-Aminofluorescein has been used to determine its ability to potentiate the antiviral activity of poly r (A-U).

References

[1] BHARATE G Y, QIN H, FANG J. Poly(Styrene-Co-Maleic Acid)-Conjugated 6-Aminofluorescein and Rhodamine Micelle as Macromolecular Fluorescent Probes for Micro-Tumors Detection and Imaging[J]. Journal of Personalized Medicine, 2022, 12. DOI:10.3390/jpm12101650.
[2] Müller, Werner EG, and Heinz Christoph Schr?der, eds. Biological Response Modifiers—Interferons, Double-Stranded RNA and 2′, 5′-Oligoadenylates. Vol. 14. Springer Science & Business Media, 2012.

Properties of 6-Aminofluorescein

Melting point: 285 °C (dec.)(lit.)
Boiling point: 481.89°C (rough estimate)
Density  1.3724 (rough estimate)
refractive index  1.5180 (estimate)
storage temp.  2-8°C
solubility  methanol: soluble1mg/mL, clear, yellow to very dark yellow-orange
form  Solid
pka 9.34±0.20(Predicted)
color  Yellow to Orange
BRN  51708
Stability: Light and Moisture Sensitive
InChI InChI=1S/C20H13NO5/c21-10-1-4-13-16(7-10)20(26-19(13)24)14-5-2-11(22)8-17(14)25-18-9-12(23)3-6-15(18)20/h1-9,22-23H,21H2
CAS DataBase Reference 51649-83-3(CAS DataBase Reference)

Safety information for 6-Aminofluorescein

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 6-Aminofluorescein

InChIKey YOAWSYSKQHLFPM-UHFFFAOYSA-N
SMILES C12(C3=C(C=C(O)C=C3)OC3=C1C=CC(O)=C3)C1=C(C=CC(N)=C1)C(=O)O2

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