6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
Synonym(s):2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid;
- CAS NO.：153559-76-3
- Empirical Formula: C24H29NO2
- Molecular Weight: 363.49
- MDL number: MFCD01758574
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
![6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Structural](https://img.chemicalbook.in/CAS/GIF/153559-76-3.gif)
What is 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID?
Chemical properties
Off-White Solid
The Uses of 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
What are the applications of Application
LG 100268 is a potent agonist of RXR
Biochem/physiol Actions
LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.
storage
Store at -20°C
Properties of 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
| Melting point: | 275-277°C |
| Boiling point: | 487.0±33.0 °C(Predicted) |
| Density | 1.115±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: ≥5mg/mL (warmed) |
| pka | 2.35±0.10(Predicted) |
| form | powder |
| color | white to beige |
Safety information for 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
Computed Descriptors for 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
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