5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
Synonym(s):5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione;CG53353, DAPH 2, 4,5-bis(4-Fluoroanilino)-phthalimide, CGP 53 353;DAPH 2;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem
- CAS NO.：145915-60-2
- Empirical Formula: C20H13F2N3O2
- Molecular Weight: 365.33
- MDL number: MFCD00938569
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
![5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Structural](https://img.chemicalbook.in/CAS/GIF/145915-60-2.gif)
What is 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE?
The Uses of 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines.
What are the applications of Application
DAPH-7 is a highly selective PKCβII inhibitor
Definition
ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides.
Biological Activity
Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro .
storage
Store at RT
Properties of 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | solid |
| color | orange |
Safety information for 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
Computed Descriptors for 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
New Products
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